Our Heart & Vascular Center team continues to build on our long and distinguished history by offering innovative, compassionate, and patient-centered care and pioneering groundbreaking advances in the treatment of cardiovascular care.

Prem Shekar, MD

Prem Shekar, MD
Dr. Prem S. Shekar is the chief of the Division of Cardiac Surgery and surgical director of the Heart and Vascular Center at Brigham and Women's Hospital. In addition, he is an assistant professor of surgery at Harvard Medical School. Dr. Shekar received his medical degree from Bangalore Medical College and Research Institute in India. He completed two residencies in India: one in surgery at Command Hospital Airforce and the other in cardiothoracic surgery at Jawaharlal Institute of Postgraduate Medical Education and Research. Dr. Shekar then completed cardiothoracic surgery residency programs at Fremantle Hospital and Royal Adelaide Hospital, both in Australia. He also completed a cardiac surgery fellowship at Brigham and Women's Hospital.  He is also a fellow of the Royal College of Surgeons of Edinburgh.

His practice encompasses the entire spectrum of adult cardiac surgery, including primary and coronary artery bypass grafting, repair or replacement for valvular heart disease, as well as resection and replacement of aneurysms. Dr. Shekar's clinical interests include surgical treatment of hypertrophic cardiomyopathy, surgical correction of aortic root and mitral valve pathologies in patients with Marfan's and Loeys-Dietz syndrome and other connective tissue disorders; minimally invasive valve surgery, surgery for adult congenital heart disease and radiation-induced heart disease. Dr. Shekar was the principal investigator in the CIMIT-funded Hybrid Cardiovascular Operating Room project and the site principal investigator for the HeartMate II Pivotal trial, which studied a novel ventricular assist device as permanent therapy for patients with advanced heart disease who are not candidates for transplantation.

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Mandeep R. Mehra, MD

Mandeep R. Mehra, MD
Dr. Mandeep R. Mehra is the medical director of the Brigham and Women's Hospital Heart & Vascular Center. He specializes in cardiovascular medicine and cardiac transplant and is a professor of medicine at Harvard Medical School.

Dr. Mehra received his medical degree from Mahatma Gandhi Institute of Medical Sciences in Maharashtra, India. He completed a residency in internal medicine at Mount Carmel Medical Center in Columbus, as well as fellowships in cardiovascular disease and advanced heart failure and transplant cardiology at Ochsner Clinic Foundation Hospital in New Orleans. Dr. Mehra is board certified in internal medicine, cardiovascular disease, and advanced heart failure and transplant cardiology.

Dr. Mehra's clinical interests include advanced heart failure and cardiac transplantation. The author of over 200 peer-reviewed publications, his research has received support from the National Heart, Lung and Blood Institute. His recent studies focus on immunosuppression, proteomic and genomic biomarkers in peripheral blood for the prediction of cardiac rejection, as well as the effects of tobacco exposure on donor and recipient heart outcomes. Dr. Mehra is also editor-in-chief of The Journal of Heart and Lung Transplantation.

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Samuel Z. Goldhaber, MD

Samuel  Z. Goldhaber, MD 
Dr. Samuel  Z. Goldhaber is the section head for Vascular Medicine and director of the Thrombosis Research Group within the Cardiovascular Medicine Division of Brigham and Women's Hospital (BWH). He is a professor of medicine at Harvard Medical School (HMS). He received his medical degree from HMS. He completed his internal medicine residency at Peter Bent Brigham Hospital (now BWH) and was appointed as a chief medical resident at the Veterans Administration Medical Center in West Roxbury (now VA Boston Healthcare System). He then completed his cardiology fellowship at Peter Bent Brigham Hospital (now BWH). Dr. Goldhaber is board certified in cardiovascular disease and internal medicine.

Dr. Goldhaber's clinical interests include general cardiology as well as novel oral anticoagulants, stroke prevention in atrial fibrillation, reduction of inflammation to prevent myocardial infarction, and the epidemiology, management, and prevention of pulmonary embolism (PE) and deep vein thrombosis (DVT). His extensive research and publications focus on PE, DVT, and stroke prevention in atrial fibrillation. He chairs the steering committee of the ATTRACT Trial, which is studying the optimal method to manage massive DVT. He is principal investigator of clinical and observational trials of PE and DVT prevention and treatment as well as of stroke prevention in atrial fibrillation. His research has received funding from the National Institutes of Health.

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Featured Programs and Leadership

Heart Rhythm Disorders Program

  • William Sauer, MD

Structural Heart Disease Program

  • Pinak B. Shah, MD, Medical Director
  • Tsuyoshi Kaneko, MD, Surgical Director

Center for Advanced Heart Failure/ Cardiomyopathy Team

  • Mandeep R. Mehra, MD

To see a list of our full cardiac care teams below:

Request an Appointment or Get a Second Opinion

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